Polymorphism of the TMPRSS2 gene relating to COVID-19 subceptibility in Vietnamese population

Recently, a contagious lung disease named coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2), rapidly spread worldwide and has many serious consequences for human health. Human genetic polymorphisms may contribute to the variation of incidence, mortality as well severity COVID-19. To date, this factor in Vietnamese population remains unknown. A cellular protease termed transmembrane serine (TMPRSS2) was found play vital role entry SARS-CoV-2 into host cells. In study, we investigated TMPRSS2 gene from 270 whole exome sequencing data peoples. We also employed bioinformatics tools including SIFT, Polyphen-2, PROVEAN predict possible function missense variants. total 34 variants were identified, which, 29 non-coding regions 14 coding regions. Variants exons included seven synonymous non-synonymous point mutations, one which novel mutation (c.A1336C/p.R446R). Mutation c.G589A/p.V197M (rs12329760) possesses highest frequency predicted have ability damage protein SIFT Polyphen-2. addition, damaging possibility c.T244G/p.Y82D c.C896T/p.A299V This study contributes understanding databases relating susceptibility